BTG Fall 2018

HAS BEEN SHOWN TO PREVENT OVERDOSES AND STOP OPIOID “DESIGNER DRUGS” FROM AFFECTING THE BRAIN vaccine ? ARE A new

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Treating addiction with vaccines is a relatively new idea with many unanswered questions Treating ad iction with vac ines is a relatively new idea with many unanswered questions

that arise out of a lack of research. But a new study suggests vaccinating against illicit drugs is not only possible, it could be extremely effective. At the Scripps Research Institute in California, researchers were looking for a way to guard against the lethal and addictive effects of synthetic opioid “designer drugs.” A potentially deadly opioid, fentanyl, is often used as a heroin substitute or mix-in by drug dealers, so that arise out of a lack of research. But a new study sug ests vac inating against illicit drugs is not only pos ible, it could be extremely effective. At he Scrip s Research Insti ute in California, researchers were lo king for a way to guard against he lethal and ad ictive effects of synthetic opioid “designer drugs.” A potentially deadly opioid, fentanyl, is often used as a heroin substi ute or mix-in by drug dealers, so researchers developed a vaccine to try to mitigate its effects. Researchers injected mice with three rounds of the vaccine and then exposed them to doses of fentanyl. They found the vaccinated mice did not display any “high” behaviors even months after the last series of vaccine injections. Researchers say the immune systems of the mice developed antibodies that successfully blocked the drug from reaching the brain. “The results were the best we’ve ever seen for any drug vaccine,” says Paul Bremer, a graduate student at Scripps Research Institute who worked on the study. researchers developed a vac ine to try to mit gate its effects. Researchers injected mice with thre rounds of the vac ine and then exposed them to doses of entanyl. They found the vac inated mice did not display any “high” behaviors even months after the last series of vac ine injections. Researchers ay the im une systems of the mice developed antibodies that suc es fully blocked the drug from reaching the brain. “The results were the best we’ve ever se n for any drug vac ine,” says Paul Bremer, a graduate student at Scrip s Research Insti ute who worked on the study.

VACCINES THE ANSWER

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The results were the best we’ve ever seen for any drug vaccine. - Paul Bremer, Scripps Research Institute

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